American born Piller had a glittering amateur career winning four tournaments whilst at the University of Texas, El Paso (UTEP). 2007 was a fantastic year for Piller as she was also named Conference USA Individual champion, Player of the Year and the UTEP Female Athlete of the Year. This led to her turning professional in September 2007.
In 2017, she posted 5 top-10 finishes, including 4 inside the top 5, and a season-best T3 result at the Marathon Classic presented by Owns Corning & O-I. She crossed the $3 million mark in career earnings with her fourth place finish at the Pure Silk-Bahamas LPGA Classic. 2019 marks her return from maternity leave.