2010 continued in the same strong vein for Johnson when he successfully defended his AT&T Pebble Beach National Pro-Am title. Johnson had good finishes in 2010 majors, coming tied 8th at the 2010 US Open and 5th in the 2010 US PGA. Johnsons fourth career PGA Tour Victory came at the BMW Championship at Cog Hill in September. It was Johnson's fourth career PGA Tour victory. He finished the 2010 season ranked 4th on the PGA Tour money list.

In March 2011, Johnson secured runner up position at the WGC-Cadillac Championship with a two stroke lead over the rest of the field. Another second place finish came for Dustin in July at the 2011 Open Championship, this was his best major championship finish to date. As a result of this finish, Johnson moved to his highest spot in the Official World Golf Ranking at the time, seventh.

Johnson won his fifth PGA Tour title at The Barclays in 2011, beating Matt Kuchar by two strokes. He finished the 2011 season fourth in the final FedEx Cup standings.

2012 did not start as hoped for Johnson after he incurred a back injury and had to miss over two months of the 2012 season. He returned in late May at the Memorial Tournament in Ohio, finishing tied 19th. Dustin returned to form the following week when he won his sixth tour event, the FedEx St. Jude Classic in Memphis, Tennessee.